Murine Roseolovirus Induces Autoimmune Disease and Development of Autoantibodies
Background/Purpose: Murine roseolovirus (MRV) is a recently sequenced beta-herpesvirus that is a natural murine pathogen and is genetically highly related to HHV6 and HHV7. The human roseoloviruses,...
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Implications of Adopting the Newly Proposed Pediatric Rheumatology...
Background/Purpose: PRINTO recently proposed preliminary JIA classification criteria to revise the International League of Associations for Rheumatology (ILAR) criteria. The stated aim was to obtain...
View ArticleT Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children. Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes...
View ArticleSerious Infection Risk in Pediatric Patients with Low Immunoglobulin Levels...
Background/Purpose: Low immunoglobulin (Ig) levels can occur after rituximab treatment, but the clinical significance is not completely understood. Not all patients (pts) who develop low Ig levels...
View ArticleSystemic Inflammation and Cognitive Dysfunction in jSLE Patients
Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS...
View ArticleChildhood-onset Takayasu Arteritis: A Single Center Case Series of Atypical...
Background/Purpose: Childhood-onset Takayasu arteritis is a rare inflammatory vessel disease that predominantly affects the aorta and its major branches. Clinical presentation at disease onset can be...
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Using a Patient-Engaged Approach to Identify Cross-Cutting Disease Factors...
Background/Purpose: Mental health problems are common and often untreated in youth with rheumatologic disease, yet their relationship with disease features is poorly understood. We engaged patients and...
View ArticleEstablishment of a Registry for Juvenile Idiopathic Arthritis (JIA) Patients...
Background/Purpose: Patient outcomes and experiences are key components in the measurement of overall health outcomes in JIA and can be measured by validated PROMs and PREMs questionnaires. There is...
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Kawasaki Disease in Ontario Children from 1995-2017: A Population-based...
Background/Purpose: Kawasaki disease (KD) is a childhood vasculitis with rising global incidence and the most common cause of childhood acquired heart disease in the developed world. However, over the...
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Safety Analysis of Infliximab-dyyb as Compared to Infliximab in Pediatric...
Background/Purpose: Infliximab is an effective treatment for many pediatric rheumatic conditions, but high medication cost creates a barrier to patient access. Biosimilar drugs are proven to be...
View ArticleAllogeneic Hematopoietic Cell Transplantation (HCT) in the National...
Background/Purpose: The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease caused by biallelic mutations in ADA2. The diagnosis of DADA2 is made by the...
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Experience with and Management of HLH-like Toxicities Following Chimeric...
Background/Purpose: Chimeric antigen receptor T-cell (CAR-T) therapy is a highly effective form of adoptive cell immunotherapy combining antigen specific targeting capabilities with T-cell based...
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Hemophagocytic Lymphohistiocytosis (HLH) Genetic Variants in Childhood-onset...
Background/Purpose: Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyper-inflammatory syndrome characterized by excessive activation and proliferation of T-lymphocytes and macrophages....
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Prevalence of Paradoxical Psoriasis After Exposure to Tumor Necrosis Factor...
Background/Purpose: Paradoxical psoriasis after exposure to tumor necrosis factor inhibitors (TNFi) has been increasingly reported in the adult population. Systematic studies in pediatric population...
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Characteristics of the New Childhood Arthritis and Rheumatology Research...
Background/Purpose: The New CARRA Registry of Juvenile Myositis (JM) was developed in 2017 to collect 10-year longitudinal data to increase knowledge of the course of JM and facilitate clinical and...
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Patients Perspectives on Living with a Systemic Autoinflammatory Disease:...
Background/Purpose: Systemic autoinflammatory diseases (SAIDs) encompass multiple clinical entities in which spontaneous inflammation occurs due to dysregulation of the innate immune response. The...
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Sun Protection Use in Patients Followed in a Pediatric Rheumatology Clinic in...
Background/Purpose: Exposure to sunlight has been implicated as a major contributing factor in the pathogenesis of systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Despite this...
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Allogenic Hematopoietic Stem Cell Transplantation for Refractory Childhood...
Background/Purpose: Patients with refractory rheumatic diseases face poor quality of life, long-term sequelae and life-threatening complications. With advances in allogenic hematopoietic stem cell...
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Non-criteria Antiphospholipid Antibodies Associated with Pediatric Rheumatic...
Background/Purpose: Non-criteria antiphospholipid antibodies (NC-aPL) bind molecules such as phosphatidylethanolamine (PE), phosphatidylserine (PS), and prothrombin (Pt), but not the targets of routine...
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Patient-Proxy Agreement on Mental Health and Neuropsychological Symptoms...
Background/Purpose: Adolescents with juvenile fibromyalgia syndrome (JFMS) present with a myriad of mental health and neuropsychological symptoms, including dyscognition (“brain fog”); however,...
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