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Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm...
Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly...
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Implementing Treat to Target Approach in the Care of Juvenile Idiopathic...
Background/Purpose: In 2018, an international task force published a recommended Treat to Target (T2T) approach to JIA treatment. This treatment paradigm involves setting a treatment target of disease...
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Immersive Virtual Reality for Management of Amplified Musculoskeletal Pain...
Background/Purpose: Amplified Musculoskeletal Pain Syndrome (AMPS), a chronic pain syndrome with excessive musculoskeletal pain without a primary organic etiology, has a high prevalence in adolescents....
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Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in...
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody...
View ArticleMusculoskeletal Ultrasound Study in Childhood Arthritis: A Limited Examination
Background/Purpose: A challenge in the management of Juvenile Idiopathic Arthritis (JIA) is most of the core set of assessment measurements are subjective by nature. A validated, accessible, objective...
View ArticleEarly Treatment with Anakinra in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) should be considered as a polygenic autoinflammatory disease. Interleukin 1 (IL-1) has been shown to be a major mediator of the...
View ArticleAnti-Mitochondrial Autoantibodies Are Associated with Dysphagia in Juvenile...
Background/Purpose: We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in both juvenile-(JM) and adult-onset myositis cohorts and investigated phenotype differences between juvenile...
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Baseline Kidney Biopsy in Lupus Patients Without Renal Manifestations....
Background/Purpose: Lupus nephritis (LN) is seen in 20–75% of patients with pediatric Systemic Lupus Erythematosus (SLE). LN may present with abnormal urinary findings and/or renal impairment (overt...
View ArticleLong Term Safety of Biologics and Biosimilars in Pediatric Rheumatic...
Background/Purpose: The use of biologic response modifiers(BRMs) is associated with an increased risk of infections. We also use biosimilars for two reasons:1. originator not available, like...
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Chest Computed Tomography Manifestations in Childhood-Onset Systemic Lupus...
Background/Purpose: Intrathoracic involvement in adults with systemic lupus erythematosus (SLE) is relatively common, particularly pleural disease. The prevalence of intrathoracic involvement in...
View ArticleFunctional Characterization of PLCG2 Mutations Found in Subjects with...
Background/Purpose: PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID) are autosomal dominant diseases caused by mutations of PLCG2. APLAID is...
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Chronic Fatigue Symptoms in Children with Abrupt Early-onset OCD And/or PANS
Background/Purpose: Chronic Fatigue Syndrome (CFS)/Myalgic encephalomyelitis (ME) affects roughly 2.5 million people in the United States, and is challenging both in diagnosis and treatment. Many case...
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Clinical Characteristics and Outcomes of Critically Ill Children Requiring...
Background/Purpose: Pediatric rheumatology has been an evolving subspecialty over the last few decades with a continued increase in the both the number and severity of rheumatic diseases requiring...
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Patterns of Etanercept Use in the Childhood Arthritis and Rheumatology...
Background/Purpose: Etanercept (ETN) is an anti-tumor necrosis factor (anti-TNF) therapy that is FDA approved for the treatment of polyarticular juvenile idiopathic arthritis (JIA). This study...
View ArticleDoes Anakinra Dampen Neuronal Damage in Children with Febrile-Infection...
Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile...
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Kawasaki Disease Shock Syndrome: A Single Center Cohort
Background/Purpose: Kawasaki disease (KD) is a well described vasculitis of childhood that is the leading cause of acquired heart disease in developed countries. Kawasaki disease shock syndrome (KDSS)...
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Development of CARRA Consensus Treatment Plans for Severe ANCA-associated...
Background/Purpose: Randomized trials for pediatric ANCA-associated vasculitis (ped-AAV) have not been feasible because of its rarity, therefore adult treatment strategies are usually adapted for...
View ArticleNasopharyngeal Pneumococcus Colonization in Patients with Childhood Onset...
Background/Purpose: Streptococcus pneumoniae (S. pneumoniae) may lead to severe life-threatening infections in both the general and immunocompromised population. Patients diagnosed with Systemic Lupus...
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Medication Related Decision-Making in Parents of Children with Juvenile...
Background/Purpose: Outcomes for juvenile idiopathic arthritis (JIA) have improved with use of disease-modifying anti-rheumatic drugs (DMARDs) and biologics. Despite this, the decision by a parent to...
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