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Abatacept Treatment Reduces Cutaneous and Joint Activity in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease commonly associated with damage. Damage includes dyspigmentation, tissue atrophy, arthropathy, hemiatrophy, vision...
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Incidence and Risk Factors of Hypogammaglobulinemia and Infectious...
Background/Purpose: B-cell depletion therapy has increasingly been used for the treatment of childhood-onset rheumatic diseases. Previous studies investigating whether rituximab results in increased...
View ArticleCD3 Downregulation on T-cells Is Concomitant with Arginase Upregulation on...
Background/Purpose: Rationale: Juvenile idiopathic arthritis (JIA) is an inflammatory autoimmune disorder driven by dysfunction of the joint tissue and abnormal immune responses. As deep phenotyping of...
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Failure of Methotrexate Monotherapy and Subsequent Response to Tumor Necrosis...
Background/Purpose: Pediatric non-infectious uveitis is often treated with systemic immunomodulators in a step-wise fashion, with methotrexate (MTX) followed by tumor necrosis factor alpha inhibitors...
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Predictors of Moderate/High Disease Activity in Childhood-Onset Systemic...
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE), but there are limited studies identifying predictors...
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Medication Adherence in Adolescents and Young Adults with Childhood Onset SLE
Background/Purpose: Compared to adults with SLE, young patients with SLE face particular challenges, including more severe disease, more renal involvement and medications side effects like growth...
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Therapeutic Interferon Gamma Neutralization with Emapalumab in Patients with...
Background/Purpose: Interferon gamma (IFNγ) is a pivotal mediator of HLH. Emapalumab (a fully human anti-IFNγ monoclonal antibody) is efficacious in patients with primary HLH. In autoinflammatory...
View ArticleThe First 18 Months of a Pediatric Rheumatology Service at a Tertiary...
Background/Purpose: Pediatric rheumatic diseases impart a significant disease burden upon children and their families with the potential to cause diminished quality of life and significant direct and...
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Novel Algorithm to Increase Sensitivity of Detecting Active Arthritis in...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The use of infrared thermal imaging for screening JIA has not utilized standardized image...
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The Impact of Psychiatric Diagnosis and Treatment on Medication Adherence in...
Background/Purpose: Youth with systemic lupus erythematosus (SLE) experience significant health care burden and high rates of psychiatric disorders. Optimizing medication adherence is critical for...
View ArticleGenetic Susceptibility Loci for Periodic Fever, Aphthous Stomatitis,...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome of childhood. Although familial clustering of the...
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Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide...
Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes...
View ArticleImmunological Profiles Following Treatment with Rituximab in Autoimmune Disease
Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), and Autoimmune Encephallitis (AE) arise due to dysregulation of the immune system...
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Disease Characteristics and Medication Utilization in Lupus Nephritis...
Background/Purpose: Lupus nephritis associated with childhood-onset systemic lupus erythematosus (cSLE) is a significant risk factor for long-term morbidity and mortality, but little is known regarding...
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Pyoderma Gangrenosum Ulceration as a Presenting Feature of Pediatric...
Background/Purpose: GPA is a form of anti-neutrophilic cytoplasmic antibody vasculitis affecting small to medium sized vessels and involves most commonly the kidneys and the respiratory tract. Skin...
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Traditional Laboratory Parameters and New Biomarkers in Macrophage Activation...
Background/Purpose: Macrophage Activation Syndrome (MAS) and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) are hyperinflammatory conditions caused by a cytokine storm. Prompt recognition and...
View ArticleMusculoskeletal Ultrasound Assessment in Pediatric Knee Hypermobility
Background/Purpose: While musculoskeletal ultrasound (MSUS) use in pediatric rheumatology is becoming more common, the majority of pediatric MSUS literature continues to focus on ultrasound findings in...
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Patients with Juvenile Idiopathic Arthritis in the Childhood Arthritis and...
Background/Purpose: In July 2015, the CARRA Registry was re-established as a multi-center observational study that collects essential data from patients with childhood-onset rheumatic diseases. The...
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