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Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset...
Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al.,...
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Practice Patterns for Consulting Pediatric Rheumatology in a Large Pediatric...
Background/Purpose: Pediatric Rheumatology (PR) is a young and still evolving subspecialty. In addition to traditional rheumatic diseases, there has been an increased prevalence of emerging...
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Carbohydrate and Sugar Intake Predict Pain in Teens with Active JIA Disease...
Background/Purpose: The purpose of this study is to define the relationships between pain and carbohydrate metabolism in teens with active juvenile idiopathic arthritis (JIA), teens with JIA in...
View ArticleReversible Hepatotoxicity to IL-1/IL-6 Blockade in Pediatric Patients with...
Background/Purpose: Treatment for systemic JIA (sJIA) complicated by macrophage activation syndrome (MAS) may involve blockade of IL-1 and IL-6. There are reports of adults with rheumatoid arthritis...
View ArticleWorsening Disease Activity and Inability to Taper Corticosteroids in an...
Background/Purpose: Transition of pediatric lupus (pSLE) patients from pediatric to adult rheumatology care is historically difficult and challenging. We aim to investigate disease activity and...
View ArticleResponse to Treatment with Intra-articular Triamcinolone Hexacetonide and...
Background/Purpose: Oligo-articular juvenile idiopathic arthritis (Oligo JIA) is the most common subtype of juvenile idiopathic arthritis. Intra-articular corticosteroid (IAC) injection is a mainstay...
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Pediatric Providers’ Perspectives on Suspected Immune-Mediated Diffuse...
Background/Purpose: Immune-mediated diffuse alveolar hemorrhage (iDAH) is a life-threatening complication of pediatric rheumatologic diseases such as vasculitis, systemic lupus erythematosus, and...
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The Childhood and Rheumatology Research Alliance Systemic Lupus Erythematosus...
Background/Purpose: Optimal therapy in childhood onset systemic lupus erythematosus (SLE) lack sufficient data to support clinical decision making. To address this knowledge gap, the Childhood...
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Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm...
Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly...
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Implementing Treat to Target Approach in the Care of Juvenile Idiopathic...
Background/Purpose: In 2018, an international task force published a recommended Treat to Target (T2T) approach to JIA treatment. This treatment paradigm involves setting a treatment target of disease...
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Anti-Citrullinated Protein Antibodies (ACPA) and Bony Erosions in...
Background/Purpose: Despite being a well-established biomarker for classification of aggressive bony disease in adults with RA, ACPA have not yet been described in the ILAR criteria for polyarticular...
View ArticleReproductive Health Concerns in Young Adults with Pediatric Onset Rheumatic...
Background/Purpose: While patients and families of those with pediatric onset rheumatic diseases have keen interest and unaddressed worry about the impact of their rheumatic disease on their current...
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Evaluation of B-cell Depletion with Rituximab and IVIG Concurrent Treatment...
Background/Purpose: Rituximab is standard therapy in treating autoimmune brain disease (ABD) including refractory autoimmune encephalitis (AE) and Neuromyelitis Optica Spectrum Disease (NMOSD)....
View ArticleA Pilot Randomized Controlled Trial of the iCanCope Pain Self-management...
Background/Purpose: Pain is the most common symptom of Juvenile Idiopathic Arthritis (JIA), a chronic childhood illness that has potentially debilitating effects on health-related quality of life...
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Risk Score of Macrophage Activation Syndrome in Patients with Systemic...
Background/Purpose: Macrophage Activation Syndrome (MAS) is a severe, life-threatening, complication of rheumatic diseases in childhood, particularly of systemic Juvenile Idiopathic Arthritis (sJIA),...
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Prosthetic Temporomandibular Joint Replacement in a Cohort of Adolescent...
Background/Purpose: Temporomandibular joint (TMJ) arthritis is present in 40-96% of children with Juvenile Idiopathic Arthritis (JIA) (1). TMJ arthritis can be difficult to identify, treat, and can...
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Levels of Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis...
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience pain and...
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Parental Adverse Childhood Experience (ACE) Exposure Is Predictive of Active...
Background/Purpose: Adverse Childhood Experiences (ACEs) have been recognized for more than two decades as risk factors for poor health outcomes in adults. Nevertheless, the impact of patient exposure...
View ArticleMyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88...
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