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Hemophagocytic Lymphohistiocytosis (HLH) Genetic Variants in Childhood-onset...
Background/Purpose: Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyper-inflammatory syndrome characterized by excessive activation and proliferation of T-lymphocytes and macrophages....
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Prevalence of Paradoxical Psoriasis After Exposure to Tumor Necrosis Factor...
Background/Purpose: Paradoxical psoriasis after exposure to tumor necrosis factor inhibitors (TNFi) has been increasingly reported in the adult population. Systematic studies in pediatric population...
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Characteristics of the New Childhood Arthritis and Rheumatology Research...
Background/Purpose: The New CARRA Registry of Juvenile Myositis (JM) was developed in 2017 to collect 10-year longitudinal data to increase knowledge of the course of JM and facilitate clinical and...
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Patients Perspectives on Living with a Systemic Autoinflammatory Disease:...
Background/Purpose: Systemic autoinflammatory diseases (SAIDs) encompass multiple clinical entities in which spontaneous inflammation occurs due to dysregulation of the innate immune response. The...
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Sun Protection Use in Patients Followed in a Pediatric Rheumatology Clinic in...
Background/Purpose: Exposure to sunlight has been implicated as a major contributing factor in the pathogenesis of systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Despite this...
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Allogenic Hematopoietic Stem Cell Transplantation for Refractory Childhood...
Background/Purpose: Patients with refractory rheumatic diseases face poor quality of life, long-term sequelae and life-threatening complications. With advances in allogenic hematopoietic stem cell...
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Non-criteria Antiphospholipid Antibodies Associated with Pediatric Rheumatic...
Background/Purpose: Non-criteria antiphospholipid antibodies (NC-aPL) bind molecules such as phosphatidylethanolamine (PE), phosphatidylserine (PS), and prothrombin (Pt), but not the targets of routine...
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Patient-Proxy Agreement on Mental Health and Neuropsychological Symptoms...
Background/Purpose: Adolescents with juvenile fibromyalgia syndrome (JFMS) present with a myriad of mental health and neuropsychological symptoms, including dyscognition (“brain fog”); however,...
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Abatacept Treatment Reduces Cutaneous and Joint Activity in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease commonly associated with damage. Damage includes dyspigmentation, tissue atrophy, arthropathy, hemiatrophy, vision...
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Incidence and Risk Factors of Hypogammaglobulinemia and Infectious...
Background/Purpose: B-cell depletion therapy has increasingly been used for the treatment of childhood-onset rheumatic diseases. Previous studies investigating whether rituximab results in increased...
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Double Negative T Cells in Juvenile Dermatomyositis
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due to mutation of the...
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Measuring Decision Conflict in Parents of Children with Juvenile Idiopathic...
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) and biologic agents are routinely used in the treatment of JIA and JIA-associated uveitis (JIA-AU). Parents are often fearful,...
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Evaluating the Relationship Between Juvenile Idiopathic Arthritis Disease...
Background/Purpose: JIA – associated uveitis (JIA-U) accounts for 20-40% of childhood noninfectious uveitis and affects 10-20% of patients with JIA. Its chronic course is often painless and insidious,...
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Discovering the Implications of Adiposity in Juvenile Dermatomyositis
Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several...
View ArticleAssociations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk for poor...
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Differences in Clinical Presentation Between Israeli and United States...
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US)....
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Transition from Pediatric to Adult Rheumatology: The Clinician as a...
Background/Purpose: The transition from pediatric to adult rheumatology is linked to poor outcomes in the absence of comprehensive transition programs. Several tools are available to measure transition...
View ArticleAncestry, Demographic and Clinical Features of Israeli Periodic Fever...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology. Recently, we showed that there may be a...
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HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by fibrosis and...
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Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with...
Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies in patients suggest that...
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