Differences in Chromatin Architecture Between Treatment-Naïve Pediatric and...
Background/Purpose: Systemic lupus erythematosus (SLE) is possibly triggered by gene-environment interactions. We showed most of the SLE haplotypes contain epigenetic marks associated with enhancer...
View ArticleUse of Intravenous Pamidronate in Pediatric Leukemia Patients with...
Background/Purpose: Osteonecrosis has emerged as debilitating complication of acute pediatric lymphoblastic leukemia (pALL), with severe pain and poor functional outcome. Patients with ON of weight...
View ArticleActual Medication Usage of Patients with Juvenile Onset Systemic Lupus...
Background/Purpose: Background: Immunosuppressive therapy is the mainstay of treatment of child systemic lupus erythematosus (cSLE). However until very recently, the treatment of cSLE lacked...
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Unexpectedly High Incidence of Kawasaki Disease in a Well-Characterized...
Background/Purpose: Kawasaki Disease (KD), a systemic vasculitis of unknown etiology, is now the leading cause of acquired heart disease in children in North America. Its reported incidence varies...
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Standardizing Care and Fostering Systemic Autoinflammatory Disease (SAID)...
Background/Purpose: International registries have significantly enhanced the understanding of the genetics, phenotype, prognosis, and treatment of Systemic Autoinflammatory Diseases (SAIDs) that could...
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Patient Reported Outcomes and Resilience in Pediatric Systemic Lupus...
Background/Purpose: It has been established that pediatric Systemic Lupus Erythematous (pSLE) is associated with lower health-related quality of life (HRQOL); however, there are few studies that...
View ArticleDifferential Analysis of Serum and Urine S100 Proteins in Juvenile-onset...
Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is a systemic autoimmune/inflammatory disease. Up to 80% of patients develop lupus nephritis (LN) that affects treatment and...
View ArticleAssessing Patient Self-Reported Transition Readiness in a Large Pediatric...
Background/Purpose: Patients with childhood-onset rheumatologic diseases live well into adulthood and need effective transition from pediatric to adult medical providers. Fortunately, predictors of...
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Capturing the Range of Disease Involvement in Localized Scleroderma: The...
Background/Purpose: Localized scleroderma (LS) is a chronic inflammatory and fibrosing disease that causes both cutaneous and extracutaneous (EC) damage. EC involvement (ECI) is common in juvenile LS...
View ArticleDense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel...
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among...
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Immersive Virtual Reality for Management of Amplified Musculoskeletal Pain...
Background/Purpose: Amplified Musculoskeletal Pain Syndrome (AMPS), a chronic pain syndrome with excessive musculoskeletal pain without a primary organic etiology, has a high prevalence in adolescents....
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Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in...
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody...
View ArticleMusculoskeletal Ultrasound Study in Childhood Arthritis: A Limited Examination
Background/Purpose: A challenge in the management of Juvenile Idiopathic Arthritis (JIA) is most of the core set of assessment measurements are subjective by nature. A validated, accessible, objective...
View ArticleEarly Treatment with Anakinra in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) should be considered as a polygenic autoinflammatory disease. Interleukin 1 (IL-1) has been shown to be a major mediator of the...
View ArticleAnti-Mitochondrial Autoantibodies Are Associated with Dysphagia in Juvenile...
Background/Purpose: We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in both juvenile-(JM) and adult-onset myositis cohorts and investigated phenotype differences between juvenile...
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Baseline Kidney Biopsy in Lupus Patients Without Renal Manifestations....
Background/Purpose: Lupus nephritis (LN) is seen in 20–75% of patients with pediatric Systemic Lupus Erythematosus (SLE). LN may present with abnormal urinary findings and/or renal impairment (overt...
View ArticleLong Term Safety of Biologics and Biosimilars in Pediatric Rheumatic...
Background/Purpose: The use of biologic response modifiers(BRMs) is associated with an increased risk of infections. We also use biosimilars for two reasons:1. originator not available, like...
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Chest Computed Tomography Manifestations in Childhood-Onset Systemic Lupus...
Background/Purpose: Intrathoracic involvement in adults with systemic lupus erythematosus (SLE) is relatively common, particularly pleural disease. The prevalence of intrathoracic involvement in...
View ArticleFunctional Characterization of PLCG2 Mutations Found in Subjects with...
Background/Purpose: PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID) are autosomal dominant diseases caused by mutations of PLCG2. APLAID is...
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