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Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset...
Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al.,...
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Practice Patterns for Consulting Pediatric Rheumatology in a Large Pediatric...
Background/Purpose: Pediatric Rheumatology (PR) is a young and still evolving subspecialty. In addition to traditional rheumatic diseases, there has been an increased prevalence of emerging...
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Carbohydrate and Sugar Intake Predict Pain in Teens with Active JIA Disease...
Background/Purpose: The purpose of this study is to define the relationships between pain and carbohydrate metabolism in teens with active juvenile idiopathic arthritis (JIA), teens with JIA in...
View ArticleReversible Hepatotoxicity to IL-1/IL-6 Blockade in Pediatric Patients with...
Background/Purpose: Treatment for systemic JIA (sJIA) complicated by macrophage activation syndrome (MAS) may involve blockade of IL-1 and IL-6. There are reports of adults with rheumatoid arthritis...
View ArticleWorsening Disease Activity and Inability to Taper Corticosteroids in an...
Background/Purpose: Transition of pediatric lupus (pSLE) patients from pediatric to adult rheumatology care is historically difficult and challenging. We aim to investigate disease activity and...
View ArticleResponse to Treatment with Intra-articular Triamcinolone Hexacetonide and...
Background/Purpose: Oligo-articular juvenile idiopathic arthritis (Oligo JIA) is the most common subtype of juvenile idiopathic arthritis. Intra-articular corticosteroid (IAC) injection is a mainstay...
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Pediatric Providers’ Perspectives on Suspected Immune-Mediated Diffuse...
Background/Purpose: Immune-mediated diffuse alveolar hemorrhage (iDAH) is a life-threatening complication of pediatric rheumatologic diseases such as vasculitis, systemic lupus erythematosus, and...
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The Childhood and Rheumatology Research Alliance Systemic Lupus Erythematosus...
Background/Purpose: Optimal therapy in childhood onset systemic lupus erythematosus (SLE) lack sufficient data to support clinical decision making. To address this knowledge gap, the Childhood...
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Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm...
Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly...
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Implementing Treat to Target Approach in the Care of Juvenile Idiopathic...
Background/Purpose: In 2018, an international task force published a recommended Treat to Target (T2T) approach to JIA treatment. This treatment paradigm involves setting a treatment target of disease...
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Metabolic Profiling in Juvenile Dermatomyositis
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal...
View ArticleSerum Biomarkers in a German Cohort of Patients with Systemic Juvenile...
Background/Purpose: Most, but not all, patients with systemic juvenile idiopathic arthritis (systemic JIA) respond to therapy with interleukin (IL)-1 blocking agents but predictive factors have not...
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Pharmacist Role in an Outpatient Adolescent Complex Pediatric Lupus Clinic
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease in which the body produces pathogenic autoantibodies that cause inflammation resulting in multi-organ damage. A SLE...
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A Multinational Study of Thrombotic Microangiopathy in Macrophage Activation...
Background/Purpose: Macrophage activation syndrome (MAS) is a severe complication of rheumatologic conditions, mainly systemic juvenile idiopathic arthritis (sJIA), and is classified among the...
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The Initial Treatment of Systemic Juvenile Idiopathic Arthritis: An...
Background/Purpose: The introduction of biologic medications has revolutionized the care of children with systemic juvenile idiopathic arthritis (SJIA). Differences in treatment approaches among...
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How Do Pediatric Rheumatologists Diagnose Macrophage Activation Syndrome in...
Background/Purpose: Macrophage activation syndrome (MAS) is a feared complication in~ 10% of those systemic onset juvenile idiopathic arthritis (sJIA). Due to the similarity of MAS clinical features to...
View ArticleParsing Apart the Pain Experience: Exploring Treatment-Related Pain in...
Background/Purpose: Pain is one of the most frequently reported symptoms among children with Juvenile Idiopathic Arthritis (JIA), and in recent decades our understanding and assessment of pain has...
View ArticleNailing Down Nailfold Capillaroscopy Practices: A Survey of Pediatric...
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by vasculopathy and rash. The Bohan-Peter criteria for dermatomyositis are not ideal. There is no...
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A Randomized, Double-blind, Placebo-controlled Study of Anakinra in Pediatric...
Background/Purpose: Adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA) are rare systemic disorders of auto-inflammatory nature. There is a growing understanding that...
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Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic...
Background/Purpose: Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease classically defined by the presence of circulating antiphospholipid antibodies and either thrombotic...
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