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Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with...
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the...
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Cyclophosphamide Use in Treatment of Refractory Kawasaki Disease: A Single...
Background/Purpose: Intravenous immunoglobulin (IVIG) effectively treats vasculitis of the coronary arteries in the large majority of Kawasaki Disease (KD) patients. However, approximately 25% of...
View ArticleFeasibility and Pilot Study of Mental Health Screening in Juvenile Myositis
Background/Purpose: Juvenile myositis (JM) negatively affects health-related quality of life due to chronic weakness, skin/muscle damage, multiorgan dysfunction, and side effects of immunosuppression....
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Incidence, Contributing Factors, and Impact of Diagnostic Delay in Juvenile...
Background/Purpose: While early treatment of patients with newly diagnosed juvenile idiopathic arthritis (JIA) is an area of active study, delayed diagnosis of JIA is poorly characterized, with no...
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Treatment of Systemic Juvenile Idiopathic Arthritis in the CARRA Registry
Background/Purpose: The treatment of systemic juvenile idiopathic arthritis (SJIA) has changed dramatically over the past decade, associated with overall improvement in functional outcomes. There may...
View ArticleTubulointerstitial Nephritis and Uveitis (TINU): A Pediatric Case Series with...
Background/Purpose: Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon condition that is likely under-recognized. The ideal treatment of both renal and ophthalmologic disease...
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Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial...
Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria [1,2]....
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No-Shows: a Search for Modifiable Risk Factors
Background/Purpose: Missed ambulatory visits, or “no-shows,” limit patient access, increase costs, occupy provider time, and lead to worse patient outcomes. Only a few studies have been done in...
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Comparison of Efficacy Between Triamcinolone Acetonide and Hexacetonide...
Background/Purpose: The use of intra-articular corticosteroid (IAC) injections for Juvenile Idiopathic Arthritis (JIA) was extrapolated from its use in adult inflammatory joint diseases to achieve...
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A Preliminary Data-driven Anatomic Classification for Childhood Takayasu...
Background/Purpose: The pattern of arterial involvement and disease severity varies in those affected with cTA. Distinct imaging patterns that have some congruence with clinical phenotype may guide...
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The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4...
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified...
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Evaluation of Self-report Screening Measures in the Detection of Depressive...
Background/Purpose: Screening for co-morbid psychiatric disorder is of high clinical importance in childhood-onset systemic lupus erythematosus (cSLE). However, there are no validated screening...
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Long-Term Outcomes in Children Born to Anti-Ro and/or anti-La Positive Mothers
Background/Purpose: Neonatal Lupus Erythematosus (NLE) is an acquired autoimmune disorder associated with the transplacental passage of maternal anti-Ro and/or anti-La antibodies. NLE manifestations...
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Implications of Positive Tests for ANCA in a Pediatric Population
Background/Purpose: Testing for ANCA, particularly performed by ELISA (anti-MPO/PR3) is highly sensitive and specific for ANCA-associated vasculitis (AAV). However ANCA testing may be used in clinical...
View ArticleAdvanced Multidisciplinary Care: A New Approach to Childhood Arthritis
Background/Purpose: Many patients are overwhelmed with the diagnosis of chronic childhood arthritis and require long-term treatments. Our objective was to develop a new, child and family centered,...
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The Importance of the Patient Global Health Assessment of Disease Activity in...
Background/Purpose: Polyarticular juvenile idiopathic arthritis (pJIA) is a subtype of JIA wherein more than four joints are affected with arthritis; it is characterized by unpredictable flares and...
View ArticleClinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus...
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with...
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Change in Treatments and Outcomes After Implementation of a National...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is currently the most common childhood chronic rheumatic disease with high burden and socioeconomic costs for the patient’s family and the health...
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Association of Plasma Metabolomic Profiles with Methotrexate Response in...
Background/Purpose: Despite efforts to identify biomarkers to guide therapy in the treatment of juvenile idiopathic arthritis (JIA), drug therapy remains a trial-and-error process. In the case of...
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Increasing Rates of Standardized Depression Screening in Youth with Systemic...
Background/Purpose: Depression is common among youth with SLE. Early identification and treatment of depression has the potential to improve health outcomes for youth with SLE. Pediatric...
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