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Chronic Fatigue Symptoms in Children with Abrupt Early-onset OCD And/or PANS
Background/Purpose: Chronic Fatigue Syndrome (CFS)/Myalgic encephalomyelitis (ME) affects roughly 2.5 million people in the United States, and is challenging both in diagnosis and treatment. Many case...
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Clinical Characteristics and Outcomes of Critically Ill Children Requiring...
Background/Purpose: Pediatric rheumatology has been an evolving subspecialty over the last few decades with a continued increase in the both the number and severity of rheumatic diseases requiring...
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Patterns of Etanercept Use in the Childhood Arthritis and Rheumatology...
Background/Purpose: Etanercept (ETN) is an anti-tumor necrosis factor (anti-TNF) therapy that is FDA approved for the treatment of polyarticular juvenile idiopathic arthritis (JIA). This study...
View ArticleDoes Anakinra Dampen Neuronal Damage in Children with Febrile-Infection...
Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile...
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Kawasaki Disease Shock Syndrome: A Single Center Cohort
Background/Purpose: Kawasaki disease (KD) is a well described vasculitis of childhood that is the leading cause of acquired heart disease in developed countries. Kawasaki disease shock syndrome (KDSS)...
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Development of CARRA Consensus Treatment Plans for Severe ANCA-associated...
Background/Purpose: Randomized trials for pediatric ANCA-associated vasculitis (ped-AAV) have not been feasible because of its rarity, therefore adult treatment strategies are usually adapted for...
View ArticleNasopharyngeal Pneumococcus Colonization in Patients with Childhood Onset...
Background/Purpose: Streptococcus pneumoniae (S. pneumoniae) may lead to severe life-threatening infections in both the general and immunocompromised population. Patients diagnosed with Systemic Lupus...
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Medication Related Decision-Making in Parents of Children with Juvenile...
Background/Purpose: Outcomes for juvenile idiopathic arthritis (JIA) have improved with use of disease-modifying anti-rheumatic drugs (DMARDs) and biologics. Despite this, the decision by a parent to...
View ArticleMurine Roseolovirus Induces Autoimmune Disease and Development of Autoantibodies
Background/Purpose: Murine roseolovirus (MRV) is a recently sequenced beta-herpesvirus that is a natural murine pathogen and is genetically highly related to HHV6 and HHV7. The human roseoloviruses,...
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Implications of Adopting the Newly Proposed Pediatric Rheumatology...
Background/Purpose: PRINTO recently proposed preliminary JIA classification criteria to revise the International League of Associations for Rheumatology (ILAR) criteria. The stated aim was to obtain...
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Double Negative T Cells in Juvenile Dermatomyositis
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due to mutation of the...
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Measuring Decision Conflict in Parents of Children with Juvenile Idiopathic...
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) and biologic agents are routinely used in the treatment of JIA and JIA-associated uveitis (JIA-AU). Parents are often fearful,...
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Evaluating the Relationship Between Juvenile Idiopathic Arthritis Disease...
Background/Purpose: JIA – associated uveitis (JIA-U) accounts for 20-40% of childhood noninfectious uveitis and affects 10-20% of patients with JIA. Its chronic course is often painless and insidious,...
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Discovering the Implications of Adiposity in Juvenile Dermatomyositis
Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several...
View ArticleAssociations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk for poor...
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Differences in Clinical Presentation Between Israeli and United States...
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US)....
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Transition from Pediatric to Adult Rheumatology: The Clinician as a...
Background/Purpose: The transition from pediatric to adult rheumatology is linked to poor outcomes in the absence of comprehensive transition programs. Several tools are available to measure transition...
View ArticleAncestry, Demographic and Clinical Features of Israeli Periodic Fever...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology. Recently, we showed that there may be a...
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HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by fibrosis and...
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Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with...
Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies in patients suggest that...
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