Clik here to view.
Double Negative T Cells in Juvenile Dermatomyositis
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due to mutation of the...
View ArticleClik here to view.
Measuring Decision Conflict in Parents of Children with Juvenile Idiopathic...
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) and biologic agents are routinely used in the treatment of JIA and JIA-associated uveitis (JIA-AU). Parents are often fearful,...
View ArticleClik here to view.
Evaluating the Relationship Between Juvenile Idiopathic Arthritis Disease...
Background/Purpose: JIA – associated uveitis (JIA-U) accounts for 20-40% of childhood noninfectious uveitis and affects 10-20% of patients with JIA. Its chronic course is often painless and insidious,...
View ArticleClik here to view.
Discovering the Implications of Adiposity in Juvenile Dermatomyositis
Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several...
View ArticleAssociations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk for poor...
View ArticleClik here to view.
Differences in Clinical Presentation Between Israeli and United States...
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US)....
View ArticleClik here to view.
Transition from Pediatric to Adult Rheumatology: The Clinician as a...
Background/Purpose: The transition from pediatric to adult rheumatology is linked to poor outcomes in the absence of comprehensive transition programs. Several tools are available to measure transition...
View ArticleAncestry, Demographic and Clinical Features of Israeli Periodic Fever...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology. Recently, we showed that there may be a...
View ArticleClik here to view.
HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by fibrosis and...
View ArticleClik here to view.
Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with...
Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies in patients suggest that...
View ArticleDifferences in Chromatin Architecture Between Treatment-Naïve Pediatric and...
Background/Purpose: Systemic lupus erythematosus (SLE) is possibly triggered by gene-environment interactions. We showed most of the SLE haplotypes contain epigenetic marks associated with enhancer...
View ArticleUse of Intravenous Pamidronate in Pediatric Leukemia Patients with...
Background/Purpose: Osteonecrosis has emerged as debilitating complication of acute pediatric lymphoblastic leukemia (pALL), with severe pain and poor functional outcome. Patients with ON of weight...
View ArticleActual Medication Usage of Patients with Juvenile Onset Systemic Lupus...
Background/Purpose: Background: Immunosuppressive therapy is the mainstay of treatment of child systemic lupus erythematosus (cSLE). However until very recently, the treatment of cSLE lacked...
View ArticleClik here to view.
Unexpectedly High Incidence of Kawasaki Disease in a Well-Characterized...
Background/Purpose: Kawasaki Disease (KD), a systemic vasculitis of unknown etiology, is now the leading cause of acquired heart disease in children in North America. Its reported incidence varies...
View ArticleClik here to view.
Standardizing Care and Fostering Systemic Autoinflammatory Disease (SAID)...
Background/Purpose: International registries have significantly enhanced the understanding of the genetics, phenotype, prognosis, and treatment of Systemic Autoinflammatory Diseases (SAIDs) that could...
View ArticleClik here to view.
Patient Reported Outcomes and Resilience in Pediatric Systemic Lupus...
Background/Purpose: It has been established that pediatric Systemic Lupus Erythematous (pSLE) is associated with lower health-related quality of life (HRQOL); however, there are few studies that...
View ArticleDifferential Analysis of Serum and Urine S100 Proteins in Juvenile-onset...
Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is a systemic autoimmune/inflammatory disease. Up to 80% of patients develop lupus nephritis (LN) that affects treatment and...
View ArticleAssessing Patient Self-Reported Transition Readiness in a Large Pediatric...
Background/Purpose: Patients with childhood-onset rheumatologic diseases live well into adulthood and need effective transition from pediatric to adult medical providers. Fortunately, predictors of...
View ArticleClik here to view.
Capturing the Range of Disease Involvement in Localized Scleroderma: The...
Background/Purpose: Localized scleroderma (LS) is a chronic inflammatory and fibrosing disease that causes both cutaneous and extracutaneous (EC) damage. EC involvement (ECI) is common in juvenile LS...
View ArticleDense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel...
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among...
View Article