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Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide...
Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes...
View ArticleImmunological Profiles Following Treatment with Rituximab in Autoimmune Disease
Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), and Autoimmune Encephallitis (AE) arise due to dysregulation of the immune system...
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Disease Characteristics and Medication Utilization in Lupus Nephritis...
Background/Purpose: Lupus nephritis associated with childhood-onset systemic lupus erythematosus (cSLE) is a significant risk factor for long-term morbidity and mortality, but little is known regarding...
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Pyoderma Gangrenosum Ulceration as a Presenting Feature of Pediatric...
Background/Purpose: GPA is a form of anti-neutrophilic cytoplasmic antibody vasculitis affecting small to medium sized vessels and involves most commonly the kidneys and the respiratory tract. Skin...
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Traditional Laboratory Parameters and New Biomarkers in Macrophage Activation...
Background/Purpose: Macrophage Activation Syndrome (MAS) and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) are hyperinflammatory conditions caused by a cytokine storm. Prompt recognition and...
View ArticleMusculoskeletal Ultrasound Assessment in Pediatric Knee Hypermobility
Background/Purpose: While musculoskeletal ultrasound (MSUS) use in pediatric rheumatology is becoming more common, the majority of pediatric MSUS literature continues to focus on ultrasound findings in...
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Patients with Juvenile Idiopathic Arthritis in the Childhood Arthritis and...
Background/Purpose: In July 2015, the CARRA Registry was re-established as a multi-center observational study that collects essential data from patients with childhood-onset rheumatic diseases. The...
View ArticleExome Sequencing for Early Pediatric Systemic Lupus Erythematosus: Standard...
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with multifactorial etiology. Identification of monogenic causes of pediatric SLE (pSLE) has yielded...
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Normal MRI Appearance of Marrow Adjacent to the Sacroiliac Joints in Healthy...
Background/Purpose: MRI examination is frequently used to determine the presence of sacroiliitis in patients suspected of having inflammatory arthritis. In children and adolescents, the vascular...
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Metabolic Profiling in Juvenile Dermatomyositis
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal...
View ArticleSerum Biomarkers in a German Cohort of Patients with Systemic Juvenile...
Background/Purpose: Most, but not all, patients with systemic juvenile idiopathic arthritis (systemic JIA) respond to therapy with interleukin (IL)-1 blocking agents but predictive factors have not...
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Pharmacist Role in an Outpatient Adolescent Complex Pediatric Lupus Clinic
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease in which the body produces pathogenic autoantibodies that cause inflammation resulting in multi-organ damage. A SLE...
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A Multinational Study of Thrombotic Microangiopathy in Macrophage Activation...
Background/Purpose: Macrophage activation syndrome (MAS) is a severe complication of rheumatologic conditions, mainly systemic juvenile idiopathic arthritis (sJIA), and is classified among the...
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The Initial Treatment of Systemic Juvenile Idiopathic Arthritis: An...
Background/Purpose: The introduction of biologic medications has revolutionized the care of children with systemic juvenile idiopathic arthritis (SJIA). Differences in treatment approaches among...
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How Do Pediatric Rheumatologists Diagnose Macrophage Activation Syndrome in...
Background/Purpose: Macrophage activation syndrome (MAS) is a feared complication in~ 10% of those systemic onset juvenile idiopathic arthritis (sJIA). Due to the similarity of MAS clinical features to...
View ArticleParsing Apart the Pain Experience: Exploring Treatment-Related Pain in...
Background/Purpose: Pain is one of the most frequently reported symptoms among children with Juvenile Idiopathic Arthritis (JIA), and in recent decades our understanding and assessment of pain has...
View ArticleNailing Down Nailfold Capillaroscopy Practices: A Survey of Pediatric...
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by vasculopathy and rash. The Bohan-Peter criteria for dermatomyositis are not ideal. There is no...
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A Randomized, Double-blind, Placebo-controlled Study of Anakinra in Pediatric...
Background/Purpose: Adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA) are rare systemic disorders of auto-inflammatory nature. There is a growing understanding that...
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Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic...
Background/Purpose: Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease classically defined by the presence of circulating antiphospholipid antibodies and either thrombotic...
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