CD3 Downregulation on T-cells Is Concomitant with Arginase Upregulation on...
Background/Purpose: Rationale: Juvenile idiopathic arthritis (JIA) is an inflammatory autoimmune disorder driven by dysfunction of the joint tissue and abnormal immune responses. As deep phenotyping of...
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Failure of Methotrexate Monotherapy and Subsequent Response to Tumor Necrosis...
Background/Purpose: Pediatric non-infectious uveitis is often treated with systemic immunomodulators in a step-wise fashion, with methotrexate (MTX) followed by tumor necrosis factor alpha inhibitors...
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Predictors of Moderate/High Disease Activity in Childhood-Onset Systemic...
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE), but there are limited studies identifying predictors...
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Medication Adherence in Adolescents and Young Adults with Childhood Onset SLE
Background/Purpose: Compared to adults with SLE, young patients with SLE face particular challenges, including more severe disease, more renal involvement and medications side effects like growth...
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Therapeutic Interferon Gamma Neutralization with Emapalumab in Patients with...
Background/Purpose: Interferon gamma (IFNγ) is a pivotal mediator of HLH. Emapalumab (a fully human anti-IFNγ monoclonal antibody) is efficacious in patients with primary HLH. In autoinflammatory...
View ArticleThe First 18 Months of a Pediatric Rheumatology Service at a Tertiary...
Background/Purpose: Pediatric rheumatic diseases impart a significant disease burden upon children and their families with the potential to cause diminished quality of life and significant direct and...
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Novel Algorithm to Increase Sensitivity of Detecting Active Arthritis in...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The use of infrared thermal imaging for screening JIA has not utilized standardized image...
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The Impact of Psychiatric Diagnosis and Treatment on Medication Adherence in...
Background/Purpose: Youth with systemic lupus erythematosus (SLE) experience significant health care burden and high rates of psychiatric disorders. Optimizing medication adherence is critical for...
View ArticleGenetic Susceptibility Loci for Periodic Fever, Aphthous Stomatitis,...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome of childhood. Although familial clustering of the...
View ArticlePediatric Acute-onset Neuropsychiatric Syndrome (PANS) Is Characterized by a...
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified...
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Ongoing Disease Activity in Juvenile Idiopathic Arthritis (JIA) 18 Years...
Background/Purpose: Previously, we showed that ILAR JIA categories defined at disease onset change considerably during the first 8 years of disease course. Whether achieved remission and defined ILAR...
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Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology...
Background/Purpose: To describe characteristics of children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) enrolled in the Childhood Arthritis and Rheumatology Research...
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Defining the Prevalence of Depression and Anxiety Symptoms in Adolescents...
Background/Purpose: We aimed to evaluate the prevalence of depressive and/or anxiety symptoms in adolescents with juvenile idiopathic arthritis (JIA) and explore the association with demographic and...
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Protracted Febrile Myalgia Findings on Magnetic Resonance Imaging
Background/Purpose: Protracted febrile myalgia syndrome (PFMS) is a rare complication of familial Mediterranean fever (FMF) which consist of prolonged attack of fever, excruciating myalgia (up to 6...
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Pseudotumor Cerebri Syndrome in Children with Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that typically affects multiple organs and can lead to potentially fatal complications. Management of...
View ArticleChallenges Faced by Families of Children with an Auto-inflammatory Disease
Background/Purpose: Auto-inflammatory diseases (AIDs) are rare disorders that usually present in young children. Disease episodes, characterized by recurrent inflammation, are often frequent and...
View ArticleResolution of Coronary Artery Changes in Patients with Refractory Kawasaki...
Background/Purpose: Treatment for patients with Kawasaki Disease (KD) refractory to standard therapy is controversial. Most experts recommend a second dose of IVIG [1], and for IVIG-resistant cases,...
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Clinical Features and Outcomes in Chronic Atypical Neutrophilic Dermatosis...
Background/Purpose: Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature (CANDLE) Syndrome is an autoinflammatory interferonopathy caused by mutations in the genes...
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Chronic Non-bacterial Osteomyelitis (CNO): Correlation Between Clinical and...
Background/Purpose: Due to the lack of widely accepted diagnostic criteria or disease biomarkers, chronic non-bacterial osteomyelitis (CNO) remains a diagnosis of exclusion. Whole-body MRI (WB-MRI) has...
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