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Immersive Virtual Reality for Management of Amplified Musculoskeletal Pain...
Background/Purpose: Amplified Musculoskeletal Pain Syndrome (AMPS), a chronic pain syndrome with excessive musculoskeletal pain without a primary organic etiology, has a high prevalence in adolescents....
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Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in...
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody...
View ArticleMusculoskeletal Ultrasound Study in Childhood Arthritis: A Limited Examination
Background/Purpose: A challenge in the management of Juvenile Idiopathic Arthritis (JIA) is most of the core set of assessment measurements are subjective by nature. A validated, accessible, objective...
View ArticleEarly Treatment with Anakinra in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) should be considered as a polygenic autoinflammatory disease. Interleukin 1 (IL-1) has been shown to be a major mediator of the...
View ArticleAnti-Mitochondrial Autoantibodies Are Associated with Dysphagia in Juvenile...
Background/Purpose: We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in both juvenile-(JM) and adult-onset myositis cohorts and investigated phenotype differences between juvenile...
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Baseline Kidney Biopsy in Lupus Patients Without Renal Manifestations....
Background/Purpose: Lupus nephritis (LN) is seen in 20–75% of patients with pediatric Systemic Lupus Erythematosus (SLE). LN may present with abnormal urinary findings and/or renal impairment (overt...
View ArticleLong Term Safety of Biologics and Biosimilars in Pediatric Rheumatic...
Background/Purpose: The use of biologic response modifiers(BRMs) is associated with an increased risk of infections. We also use biosimilars for two reasons:1. originator not available, like...
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Chest Computed Tomography Manifestations in Childhood-Onset Systemic Lupus...
Background/Purpose: Intrathoracic involvement in adults with systemic lupus erythematosus (SLE) is relatively common, particularly pleural disease. The prevalence of intrathoracic involvement in...
View ArticleFunctional Characterization of PLCG2 Mutations Found in Subjects with...
Background/Purpose: PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID) are autosomal dominant diseases caused by mutations of PLCG2. APLAID is...
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Anti-Citrullinated Protein Antibodies (ACPA) and Bony Erosions in...
Background/Purpose: Despite being a well-established biomarker for classification of aggressive bony disease in adults with RA, ACPA have not yet been described in the ILAR criteria for polyarticular...
View ArticleReproductive Health Concerns in Young Adults with Pediatric Onset Rheumatic...
Background/Purpose: While patients and families of those with pediatric onset rheumatic diseases have keen interest and unaddressed worry about the impact of their rheumatic disease on their current...
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Evaluation of B-cell Depletion with Rituximab and IVIG Concurrent Treatment...
Background/Purpose: Rituximab is standard therapy in treating autoimmune brain disease (ABD) including refractory autoimmune encephalitis (AE) and Neuromyelitis Optica Spectrum Disease (NMOSD)....
View ArticleA Pilot Randomized Controlled Trial of the iCanCope Pain Self-management...
Background/Purpose: Pain is the most common symptom of Juvenile Idiopathic Arthritis (JIA), a chronic childhood illness that has potentially debilitating effects on health-related quality of life...
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Risk Score of Macrophage Activation Syndrome in Patients with Systemic...
Background/Purpose: Macrophage Activation Syndrome (MAS) is a severe, life-threatening, complication of rheumatic diseases in childhood, particularly of systemic Juvenile Idiopathic Arthritis (sJIA),...
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Prosthetic Temporomandibular Joint Replacement in a Cohort of Adolescent...
Background/Purpose: Temporomandibular joint (TMJ) arthritis is present in 40-96% of children with Juvenile Idiopathic Arthritis (JIA) (1). TMJ arthritis can be difficult to identify, treat, and can...
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Levels of Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis...
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience pain and...
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Parental Adverse Childhood Experience (ACE) Exposure Is Predictive of Active...
Background/Purpose: Adverse Childhood Experiences (ACEs) have been recognized for more than two decades as risk factors for poor health outcomes in adults. Nevertheless, the impact of patient exposure...
View ArticleMyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88...
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