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Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus
Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS) have identified more...
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Cyclophosphamide as Rescue Therapy for Kawasaki Disease with Peripheral...
Background/Purpose: Kawasaki Disease (KD) is the most common systemic vasculitis affecting children 5 years and younger. With coronary vessel involvement, KD is now the most common cause of acquired...
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Consequences and Predictors of Persisting Pain in Children with Juvenile...
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood. Pain is a distressing and prevalent feature of JIA and can decrease children’s quality of...
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A Good Inter- and Intra-observer Reliability of Subtypes in Nailfold...
Background/Purpose: In previous studies, micro-haemorrhages have often been observed in nailfold capillaroscopy in SLE.1 The interpretation of this finding is still a topic of research. Recently, a new...
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Reliability and Validity of a New Skin Activity Measure for Localized...
Background/Purpose: Juvenile localized scleroderma (jLS) is a chronic inflammatory and fibrosing disease. Treatment is directed towards controlling disease activity to minimize risk for functional...
View ArticleIs Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) a...
Background/Purpose: The improving therapeutic approach towards childhood-onset Takayasu’s arteritis (c-TA) has decreased the mortality rate over the years and increased concerns on how to improve...
View ArticleNear Infrared Indocyanine Green Imaging Reveals Altered Anatomy and...
Background/Purpose: Near infrared (NIR) imaging studies of subdermal indocyanine green (ICG) in murine models of inflammatory arthritis have established abnormal lymphatic vessel (LV) function during...
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The Efficacy and Safety of Intraarticular Injection of Triamcinolone...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. Intra-articular corticosteroids joint injection (IAJI) with Triamcinolone hexacetonide (TH) or...
View ArticleSuccessful Validation of a Rapid Point-of-care Test for Serum Calprotectin...
Background/Purpose: Treat-to-target strategies are established for the therapeutic approach to patients suffering from juvenile idiopathic arthritis (JIA). Another proposed therapeutic concept in...
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Chronic Fatigue Symptoms in Children with Abrupt Early-onset OCD And/or PANS
Background/Purpose: Chronic Fatigue Syndrome (CFS)/Myalgic encephalomyelitis (ME) affects roughly 2.5 million people in the United States, and is challenging both in diagnosis and treatment. Many case...
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Clinical Characteristics and Outcomes of Critically Ill Children Requiring...
Background/Purpose: Pediatric rheumatology has been an evolving subspecialty over the last few decades with a continued increase in the both the number and severity of rheumatic diseases requiring...
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Patterns of Etanercept Use in the Childhood Arthritis and Rheumatology...
Background/Purpose: Etanercept (ETN) is an anti-tumor necrosis factor (anti-TNF) therapy that is FDA approved for the treatment of polyarticular juvenile idiopathic arthritis (JIA). This study...
View ArticleDoes Anakinra Dampen Neuronal Damage in Children with Febrile-Infection...
Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile...
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Kawasaki Disease Shock Syndrome: A Single Center Cohort
Background/Purpose: Kawasaki disease (KD) is a well described vasculitis of childhood that is the leading cause of acquired heart disease in developed countries. Kawasaki disease shock syndrome (KDSS)...
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Development of CARRA Consensus Treatment Plans for Severe ANCA-associated...
Background/Purpose: Randomized trials for pediatric ANCA-associated vasculitis (ped-AAV) have not been feasible because of its rarity, therefore adult treatment strategies are usually adapted for...
View ArticleNasopharyngeal Pneumococcus Colonization in Patients with Childhood Onset...
Background/Purpose: Streptococcus pneumoniae (S. pneumoniae) may lead to severe life-threatening infections in both the general and immunocompromised population. Patients diagnosed with Systemic Lupus...
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Medication Related Decision-Making in Parents of Children with Juvenile...
Background/Purpose: Outcomes for juvenile idiopathic arthritis (JIA) have improved with use of disease-modifying anti-rheumatic drugs (DMARDs) and biologics. Despite this, the decision by a parent to...
View ArticleMurine Roseolovirus Induces Autoimmune Disease and Development of Autoantibodies
Background/Purpose: Murine roseolovirus (MRV) is a recently sequenced beta-herpesvirus that is a natural murine pathogen and is genetically highly related to HHV6 and HHV7. The human roseoloviruses,...
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Implications of Adopting the Newly Proposed Pediatric Rheumatology...
Background/Purpose: PRINTO recently proposed preliminary JIA classification criteria to revise the International League of Associations for Rheumatology (ILAR) criteria. The stated aim was to obtain...
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