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Hemophagocytic Lymphohistiocytosis (HLH) Genetic Variants in Childhood-onset...
Background/Purpose: Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyper-inflammatory syndrome characterized by excessive activation and proliferation of T-lymphocytes and macrophages....
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Prevalence of Paradoxical Psoriasis After Exposure to Tumor Necrosis Factor...
Background/Purpose: Paradoxical psoriasis after exposure to tumor necrosis factor inhibitors (TNFi) has been increasingly reported in the adult population. Systematic studies in pediatric population...
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Characteristics of the New Childhood Arthritis and Rheumatology Research...
Background/Purpose: The New CARRA Registry of Juvenile Myositis (JM) was developed in 2017 to collect 10-year longitudinal data to increase knowledge of the course of JM and facilitate clinical and...
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Patients Perspectives on Living with a Systemic Autoinflammatory Disease:...
Background/Purpose: Systemic autoinflammatory diseases (SAIDs) encompass multiple clinical entities in which spontaneous inflammation occurs due to dysregulation of the innate immune response. The...
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Sun Protection Use in Patients Followed in a Pediatric Rheumatology Clinic in...
Background/Purpose: Exposure to sunlight has been implicated as a major contributing factor in the pathogenesis of systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Despite this...
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Allogenic Hematopoietic Stem Cell Transplantation for Refractory Childhood...
Background/Purpose: Patients with refractory rheumatic diseases face poor quality of life, long-term sequelae and life-threatening complications. With advances in allogenic hematopoietic stem cell...
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Non-criteria Antiphospholipid Antibodies Associated with Pediatric Rheumatic...
Background/Purpose: Non-criteria antiphospholipid antibodies (NC-aPL) bind molecules such as phosphatidylethanolamine (PE), phosphatidylserine (PS), and prothrombin (Pt), but not the targets of routine...
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Patient-Proxy Agreement on Mental Health and Neuropsychological Symptoms...
Background/Purpose: Adolescents with juvenile fibromyalgia syndrome (JFMS) present with a myriad of mental health and neuropsychological symptoms, including dyscognition (“brain fog”); however,...
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Abatacept Treatment Reduces Cutaneous and Joint Activity in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease commonly associated with damage. Damage includes dyspigmentation, tissue atrophy, arthropathy, hemiatrophy, vision...
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Incidence and Risk Factors of Hypogammaglobulinemia and Infectious...
Background/Purpose: B-cell depletion therapy has increasingly been used for the treatment of childhood-onset rheumatic diseases. Previous studies investigating whether rituximab results in increased...
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Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide...
Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes...
View ArticleImmunological Profiles Following Treatment with Rituximab in Autoimmune Disease
Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), and Autoimmune Encephallitis (AE) arise due to dysregulation of the immune system...
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Disease Characteristics and Medication Utilization in Lupus Nephritis...
Background/Purpose: Lupus nephritis associated with childhood-onset systemic lupus erythematosus (cSLE) is a significant risk factor for long-term morbidity and mortality, but little is known regarding...
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Pyoderma Gangrenosum Ulceration as a Presenting Feature of Pediatric...
Background/Purpose: GPA is a form of anti-neutrophilic cytoplasmic antibody vasculitis affecting small to medium sized vessels and involves most commonly the kidneys and the respiratory tract. Skin...
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Traditional Laboratory Parameters and New Biomarkers in Macrophage Activation...
Background/Purpose: Macrophage Activation Syndrome (MAS) and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) are hyperinflammatory conditions caused by a cytokine storm. Prompt recognition and...
View ArticleMusculoskeletal Ultrasound Assessment in Pediatric Knee Hypermobility
Background/Purpose: While musculoskeletal ultrasound (MSUS) use in pediatric rheumatology is becoming more common, the majority of pediatric MSUS literature continues to focus on ultrasound findings in...
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Patients with Juvenile Idiopathic Arthritis in the Childhood Arthritis and...
Background/Purpose: In July 2015, the CARRA Registry was re-established as a multi-center observational study that collects essential data from patients with childhood-onset rheumatic diseases. The...
View ArticleExome Sequencing for Early Pediatric Systemic Lupus Erythematosus: Standard...
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with multifactorial etiology. Identification of monogenic causes of pediatric SLE (pSLE) has yielded...
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Normal MRI Appearance of Marrow Adjacent to the Sacroiliac Joints in Healthy...
Background/Purpose: MRI examination is frequently used to determine the presence of sacroiliitis in patients suspected of having inflammatory arthritis. In children and adolescents, the vascular...
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