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Metabolic Profiling in Juvenile Dermatomyositis
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal...
View ArticleSerum Biomarkers in a German Cohort of Patients with Systemic Juvenile...
Background/Purpose: Most, but not all, patients with systemic juvenile idiopathic arthritis (systemic JIA) respond to therapy with interleukin (IL)-1 blocking agents but predictive factors have not...
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Pharmacist Role in an Outpatient Adolescent Complex Pediatric Lupus Clinic
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease in which the body produces pathogenic autoantibodies that cause inflammation resulting in multi-organ damage. A SLE...
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A Multinational Study of Thrombotic Microangiopathy in Macrophage Activation...
Background/Purpose: Macrophage activation syndrome (MAS) is a severe complication of rheumatologic conditions, mainly systemic juvenile idiopathic arthritis (sJIA), and is classified among the...
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The Initial Treatment of Systemic Juvenile Idiopathic Arthritis: An...
Background/Purpose: The introduction of biologic medications has revolutionized the care of children with systemic juvenile idiopathic arthritis (SJIA). Differences in treatment approaches among...
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How Do Pediatric Rheumatologists Diagnose Macrophage Activation Syndrome in...
Background/Purpose: Macrophage activation syndrome (MAS) is a feared complication in~ 10% of those systemic onset juvenile idiopathic arthritis (sJIA). Due to the similarity of MAS clinical features to...
View ArticleParsing Apart the Pain Experience: Exploring Treatment-Related Pain in...
Background/Purpose: Pain is one of the most frequently reported symptoms among children with Juvenile Idiopathic Arthritis (JIA), and in recent decades our understanding and assessment of pain has...
View ArticleNailing Down Nailfold Capillaroscopy Practices: A Survey of Pediatric...
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by vasculopathy and rash. The Bohan-Peter criteria for dermatomyositis are not ideal. There is no...
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A Randomized, Double-blind, Placebo-controlled Study of Anakinra in Pediatric...
Background/Purpose: Adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA) are rare systemic disorders of auto-inflammatory nature. There is a growing understanding that...
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Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic...
Background/Purpose: Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease classically defined by the presence of circulating antiphospholipid antibodies and either thrombotic...
View ArticleDifferences in Chromatin Architecture Between Treatment-Naïve Pediatric and...
Background/Purpose: Systemic lupus erythematosus (SLE) is possibly triggered by gene-environment interactions. We showed most of the SLE haplotypes contain epigenetic marks associated with enhancer...
View ArticleUse of Intravenous Pamidronate in Pediatric Leukemia Patients with...
Background/Purpose: Osteonecrosis has emerged as debilitating complication of acute pediatric lymphoblastic leukemia (pALL), with severe pain and poor functional outcome. Patients with ON of weight...
View ArticleActual Medication Usage of Patients with Juvenile Onset Systemic Lupus...
Background/Purpose: Background: Immunosuppressive therapy is the mainstay of treatment of child systemic lupus erythematosus (cSLE). However until very recently, the treatment of cSLE lacked...
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Unexpectedly High Incidence of Kawasaki Disease in a Well-Characterized...
Background/Purpose: Kawasaki Disease (KD), a systemic vasculitis of unknown etiology, is now the leading cause of acquired heart disease in children in North America. Its reported incidence varies...
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Standardizing Care and Fostering Systemic Autoinflammatory Disease (SAID)...
Background/Purpose: International registries have significantly enhanced the understanding of the genetics, phenotype, prognosis, and treatment of Systemic Autoinflammatory Diseases (SAIDs) that could...
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Patient Reported Outcomes and Resilience in Pediatric Systemic Lupus...
Background/Purpose: It has been established that pediatric Systemic Lupus Erythematous (pSLE) is associated with lower health-related quality of life (HRQOL); however, there are few studies that...
View ArticleDifferential Analysis of Serum and Urine S100 Proteins in Juvenile-onset...
Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is a systemic autoimmune/inflammatory disease. Up to 80% of patients develop lupus nephritis (LN) that affects treatment and...
View ArticleAssessing Patient Self-Reported Transition Readiness in a Large Pediatric...
Background/Purpose: Patients with childhood-onset rheumatologic diseases live well into adulthood and need effective transition from pediatric to adult medical providers. Fortunately, predictors of...
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Capturing the Range of Disease Involvement in Localized Scleroderma: The...
Background/Purpose: Localized scleroderma (LS) is a chronic inflammatory and fibrosing disease that causes both cutaneous and extracutaneous (EC) damage. EC involvement (ECI) is common in juvenile LS...
View ArticleDense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel...
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among...
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