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Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with...
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the...
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Cyclophosphamide Use in Treatment of Refractory Kawasaki Disease: A Single...
Background/Purpose: Intravenous immunoglobulin (IVIG) effectively treats vasculitis of the coronary arteries in the large majority of Kawasaki Disease (KD) patients. However, approximately 25% of...
View ArticleFeasibility and Pilot Study of Mental Health Screening in Juvenile Myositis
Background/Purpose: Juvenile myositis (JM) negatively affects health-related quality of life due to chronic weakness, skin/muscle damage, multiorgan dysfunction, and side effects of immunosuppression....
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Incidence, Contributing Factors, and Impact of Diagnostic Delay in Juvenile...
Background/Purpose: While early treatment of patients with newly diagnosed juvenile idiopathic arthritis (JIA) is an area of active study, delayed diagnosis of JIA is poorly characterized, with no...
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Treatment of Systemic Juvenile Idiopathic Arthritis in the CARRA Registry
Background/Purpose: The treatment of systemic juvenile idiopathic arthritis (SJIA) has changed dramatically over the past decade, associated with overall improvement in functional outcomes. There may...
View ArticleTubulointerstitial Nephritis and Uveitis (TINU): A Pediatric Case Series with...
Background/Purpose: Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon condition that is likely under-recognized. The ideal treatment of both renal and ophthalmologic disease...
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Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial...
Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria [1,2]....
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No-Shows: a Search for Modifiable Risk Factors
Background/Purpose: Missed ambulatory visits, or “no-shows,” limit patient access, increase costs, occupy provider time, and lead to worse patient outcomes. Only a few studies have been done in...
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Comparison of Efficacy Between Triamcinolone Acetonide and Hexacetonide...
Background/Purpose: The use of intra-articular corticosteroid (IAC) injections for Juvenile Idiopathic Arthritis (JIA) was extrapolated from its use in adult inflammatory joint diseases to achieve...
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A Preliminary Data-driven Anatomic Classification for Childhood Takayasu...
Background/Purpose: The pattern of arterial involvement and disease severity varies in those affected with cTA. Distinct imaging patterns that have some congruence with clinical phenotype may guide...
View ArticleT Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children. Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes...
View ArticleSerious Infection Risk in Pediatric Patients with Low Immunoglobulin Levels...
Background/Purpose: Low immunoglobulin (Ig) levels can occur after rituximab treatment, but the clinical significance is not completely understood. Not all patients (pts) who develop low Ig levels...
View ArticleSystemic Inflammation and Cognitive Dysfunction in jSLE Patients
Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS...
View ArticleChildhood-onset Takayasu Arteritis: A Single Center Case Series of Atypical...
Background/Purpose: Childhood-onset Takayasu arteritis is a rare inflammatory vessel disease that predominantly affects the aorta and its major branches. Clinical presentation at disease onset can be...
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Using a Patient-Engaged Approach to Identify Cross-Cutting Disease Factors...
Background/Purpose: Mental health problems are common and often untreated in youth with rheumatologic disease, yet their relationship with disease features is poorly understood. We engaged patients and...
View ArticleEstablishment of a Registry for Juvenile Idiopathic Arthritis (JIA) Patients...
Background/Purpose: Patient outcomes and experiences are key components in the measurement of overall health outcomes in JIA and can be measured by validated PROMs and PREMs questionnaires. There is...
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Kawasaki Disease in Ontario Children from 1995-2017: A Population-based...
Background/Purpose: Kawasaki disease (KD) is a childhood vasculitis with rising global incidence and the most common cause of childhood acquired heart disease in the developed world. However, over the...
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Safety Analysis of Infliximab-dyyb as Compared to Infliximab in Pediatric...
Background/Purpose: Infliximab is an effective treatment for many pediatric rheumatic conditions, but high medication cost creates a barrier to patient access. Biosimilar drugs are proven to be...
View ArticleAllogeneic Hematopoietic Cell Transplantation (HCT) in the National...
Background/Purpose: The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease caused by biallelic mutations in ADA2. The diagnosis of DADA2 is made by the...
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Experience with and Management of HLH-like Toxicities Following Chimeric...
Background/Purpose: Chimeric antigen receptor T-cell (CAR-T) therapy is a highly effective form of adoptive cell immunotherapy combining antigen specific targeting capabilities with T-cell based...
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