T Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children. Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes...
View ArticleSerious Infection Risk in Pediatric Patients with Low Immunoglobulin Levels...
Background/Purpose: Low immunoglobulin (Ig) levels can occur after rituximab treatment, but the clinical significance is not completely understood. Not all patients (pts) who develop low Ig levels...
View ArticleSystemic Inflammation and Cognitive Dysfunction in jSLE Patients
Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS...
View ArticleChildhood-onset Takayasu Arteritis: A Single Center Case Series of Atypical...
Background/Purpose: Childhood-onset Takayasu arteritis is a rare inflammatory vessel disease that predominantly affects the aorta and its major branches. Clinical presentation at disease onset can be...
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Using a Patient-Engaged Approach to Identify Cross-Cutting Disease Factors...
Background/Purpose: Mental health problems are common and often untreated in youth with rheumatologic disease, yet their relationship with disease features is poorly understood. We engaged patients and...
View ArticleEstablishment of a Registry for Juvenile Idiopathic Arthritis (JIA) Patients...
Background/Purpose: Patient outcomes and experiences are key components in the measurement of overall health outcomes in JIA and can be measured by validated PROMs and PREMs questionnaires. There is...
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Kawasaki Disease in Ontario Children from 1995-2017: A Population-based...
Background/Purpose: Kawasaki disease (KD) is a childhood vasculitis with rising global incidence and the most common cause of childhood acquired heart disease in the developed world. However, over the...
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Safety Analysis of Infliximab-dyyb as Compared to Infliximab in Pediatric...
Background/Purpose: Infliximab is an effective treatment for many pediatric rheumatic conditions, but high medication cost creates a barrier to patient access. Biosimilar drugs are proven to be...
View ArticleAllogeneic Hematopoietic Cell Transplantation (HCT) in the National...
Background/Purpose: The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease caused by biallelic mutations in ADA2. The diagnosis of DADA2 is made by the...
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Experience with and Management of HLH-like Toxicities Following Chimeric...
Background/Purpose: Chimeric antigen receptor T-cell (CAR-T) therapy is a highly effective form of adoptive cell immunotherapy combining antigen specific targeting capabilities with T-cell based...
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Anti-Citrullinated Protein Antibodies (ACPA) and Bony Erosions in...
Background/Purpose: Despite being a well-established biomarker for classification of aggressive bony disease in adults with RA, ACPA have not yet been described in the ILAR criteria for polyarticular...
View ArticleReproductive Health Concerns in Young Adults with Pediatric Onset Rheumatic...
Background/Purpose: While patients and families of those with pediatric onset rheumatic diseases have keen interest and unaddressed worry about the impact of their rheumatic disease on their current...
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Evaluation of B-cell Depletion with Rituximab and IVIG Concurrent Treatment...
Background/Purpose: Rituximab is standard therapy in treating autoimmune brain disease (ABD) including refractory autoimmune encephalitis (AE) and Neuromyelitis Optica Spectrum Disease (NMOSD)....
View ArticleA Pilot Randomized Controlled Trial of the iCanCope Pain Self-management...
Background/Purpose: Pain is the most common symptom of Juvenile Idiopathic Arthritis (JIA), a chronic childhood illness that has potentially debilitating effects on health-related quality of life...
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Risk Score of Macrophage Activation Syndrome in Patients with Systemic...
Background/Purpose: Macrophage Activation Syndrome (MAS) is a severe, life-threatening, complication of rheumatic diseases in childhood, particularly of systemic Juvenile Idiopathic Arthritis (sJIA),...
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Prosthetic Temporomandibular Joint Replacement in a Cohort of Adolescent...
Background/Purpose: Temporomandibular joint (TMJ) arthritis is present in 40-96% of children with Juvenile Idiopathic Arthritis (JIA) (1). TMJ arthritis can be difficult to identify, treat, and can...
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Levels of Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis...
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience pain and...
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Parental Adverse Childhood Experience (ACE) Exposure Is Predictive of Active...
Background/Purpose: Adverse Childhood Experiences (ACEs) have been recognized for more than two decades as risk factors for poor health outcomes in adults. Nevertheless, the impact of patient exposure...
View ArticleMyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88...
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