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Levels of Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis...
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience pain and...
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Parental Adverse Childhood Experience (ACE) Exposure Is Predictive of Active...
Background/Purpose: Adverse Childhood Experiences (ACEs) have been recognized for more than two decades as risk factors for poor health outcomes in adults. Nevertheless, the impact of patient exposure...
View ArticleMyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88...
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Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with...
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the...
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Cyclophosphamide Use in Treatment of Refractory Kawasaki Disease: A Single...
Background/Purpose: Intravenous immunoglobulin (IVIG) effectively treats vasculitis of the coronary arteries in the large majority of Kawasaki Disease (KD) patients. However, approximately 25% of...
View ArticleFeasibility and Pilot Study of Mental Health Screening in Juvenile Myositis
Background/Purpose: Juvenile myositis (JM) negatively affects health-related quality of life due to chronic weakness, skin/muscle damage, multiorgan dysfunction, and side effects of immunosuppression....
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Incidence, Contributing Factors, and Impact of Diagnostic Delay in Juvenile...
Background/Purpose: While early treatment of patients with newly diagnosed juvenile idiopathic arthritis (JIA) is an area of active study, delayed diagnosis of JIA is poorly characterized, with no...
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Treatment of Systemic Juvenile Idiopathic Arthritis in the CARRA Registry
Background/Purpose: The treatment of systemic juvenile idiopathic arthritis (SJIA) has changed dramatically over the past decade, associated with overall improvement in functional outcomes. There may...
View ArticleTubulointerstitial Nephritis and Uveitis (TINU): A Pediatric Case Series with...
Background/Purpose: Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon condition that is likely under-recognized. The ideal treatment of both renal and ophthalmologic disease...
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Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial...
Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria [1,2]....
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No-Shows: a Search for Modifiable Risk Factors
Background/Purpose: Missed ambulatory visits, or “no-shows,” limit patient access, increase costs, occupy provider time, and lead to worse patient outcomes. Only a few studies have been done in...
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Comparison of Efficacy Between Triamcinolone Acetonide and Hexacetonide...
Background/Purpose: The use of intra-articular corticosteroid (IAC) injections for Juvenile Idiopathic Arthritis (JIA) was extrapolated from its use in adult inflammatory joint diseases to achieve...
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A Preliminary Data-driven Anatomic Classification for Childhood Takayasu...
Background/Purpose: The pattern of arterial involvement and disease severity varies in those affected with cTA. Distinct imaging patterns that have some congruence with clinical phenotype may guide...
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Double Negative T Cells in Juvenile Dermatomyositis
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due to mutation of the...
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Measuring Decision Conflict in Parents of Children with Juvenile Idiopathic...
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) and biologic agents are routinely used in the treatment of JIA and JIA-associated uveitis (JIA-AU). Parents are often fearful,...
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Evaluating the Relationship Between Juvenile Idiopathic Arthritis Disease...
Background/Purpose: JIA – associated uveitis (JIA-U) accounts for 20-40% of childhood noninfectious uveitis and affects 10-20% of patients with JIA. Its chronic course is often painless and insidious,...
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Discovering the Implications of Adiposity in Juvenile Dermatomyositis
Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several...
View ArticleAssociations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk for poor...
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Differences in Clinical Presentation Between Israeli and United States...
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US)....
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