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Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide...
Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes...
View ArticleImmunological Profiles Following Treatment with Rituximab in Autoimmune Disease
Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), and Autoimmune Encephallitis (AE) arise due to dysregulation of the immune system...
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Disease Characteristics and Medication Utilization in Lupus Nephritis...
Background/Purpose: Lupus nephritis associated with childhood-onset systemic lupus erythematosus (cSLE) is a significant risk factor for long-term morbidity and mortality, but little is known regarding...
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Pyoderma Gangrenosum Ulceration as a Presenting Feature of Pediatric...
Background/Purpose: GPA is a form of anti-neutrophilic cytoplasmic antibody vasculitis affecting small to medium sized vessels and involves most commonly the kidneys and the respiratory tract. Skin...
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Traditional Laboratory Parameters and New Biomarkers in Macrophage Activation...
Background/Purpose: Macrophage Activation Syndrome (MAS) and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) are hyperinflammatory conditions caused by a cytokine storm. Prompt recognition and...
View ArticleMusculoskeletal Ultrasound Assessment in Pediatric Knee Hypermobility
Background/Purpose: While musculoskeletal ultrasound (MSUS) use in pediatric rheumatology is becoming more common, the majority of pediatric MSUS literature continues to focus on ultrasound findings in...
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Patients with Juvenile Idiopathic Arthritis in the Childhood Arthritis and...
Background/Purpose: In July 2015, the CARRA Registry was re-established as a multi-center observational study that collects essential data from patients with childhood-onset rheumatic diseases. The...
View ArticleExome Sequencing for Early Pediatric Systemic Lupus Erythematosus: Standard...
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with multifactorial etiology. Identification of monogenic causes of pediatric SLE (pSLE) has yielded...
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Normal MRI Appearance of Marrow Adjacent to the Sacroiliac Joints in Healthy...
Background/Purpose: MRI examination is frequently used to determine the presence of sacroiliitis in patients suspected of having inflammatory arthritis. In children and adolescents, the vascular...
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Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset...
Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al.,...
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Practice Patterns for Consulting Pediatric Rheumatology in a Large Pediatric...
Background/Purpose: Pediatric Rheumatology (PR) is a young and still evolving subspecialty. In addition to traditional rheumatic diseases, there has been an increased prevalence of emerging...
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Carbohydrate and Sugar Intake Predict Pain in Teens with Active JIA Disease...
Background/Purpose: The purpose of this study is to define the relationships between pain and carbohydrate metabolism in teens with active juvenile idiopathic arthritis (JIA), teens with JIA in...
View ArticleReversible Hepatotoxicity to IL-1/IL-6 Blockade in Pediatric Patients with...
Background/Purpose: Treatment for systemic JIA (sJIA) complicated by macrophage activation syndrome (MAS) may involve blockade of IL-1 and IL-6. There are reports of adults with rheumatoid arthritis...
View ArticleWorsening Disease Activity and Inability to Taper Corticosteroids in an...
Background/Purpose: Transition of pediatric lupus (pSLE) patients from pediatric to adult rheumatology care is historically difficult and challenging. We aim to investigate disease activity and...
View ArticleResponse to Treatment with Intra-articular Triamcinolone Hexacetonide and...
Background/Purpose: Oligo-articular juvenile idiopathic arthritis (Oligo JIA) is the most common subtype of juvenile idiopathic arthritis. Intra-articular corticosteroid (IAC) injection is a mainstay...
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Pediatric Providers’ Perspectives on Suspected Immune-Mediated Diffuse...
Background/Purpose: Immune-mediated diffuse alveolar hemorrhage (iDAH) is a life-threatening complication of pediatric rheumatologic diseases such as vasculitis, systemic lupus erythematosus, and...
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The Childhood and Rheumatology Research Alliance Systemic Lupus Erythematosus...
Background/Purpose: Optimal therapy in childhood onset systemic lupus erythematosus (SLE) lack sufficient data to support clinical decision making. To address this knowledge gap, the Childhood...
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Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm...
Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly...
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Implementing Treat to Target Approach in the Care of Juvenile Idiopathic...
Background/Purpose: In 2018, an international task force published a recommended Treat to Target (T2T) approach to JIA treatment. This treatment paradigm involves setting a treatment target of disease...
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