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Metabolic Profiling in Juvenile Dermatomyositis
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal...
View ArticleSerum Biomarkers in a German Cohort of Patients with Systemic Juvenile...
Background/Purpose: Most, but not all, patients with systemic juvenile idiopathic arthritis (systemic JIA) respond to therapy with interleukin (IL)-1 blocking agents but predictive factors have not...
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Pharmacist Role in an Outpatient Adolescent Complex Pediatric Lupus Clinic
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease in which the body produces pathogenic autoantibodies that cause inflammation resulting in multi-organ damage. A SLE...
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A Multinational Study of Thrombotic Microangiopathy in Macrophage Activation...
Background/Purpose: Macrophage activation syndrome (MAS) is a severe complication of rheumatologic conditions, mainly systemic juvenile idiopathic arthritis (sJIA), and is classified among the...
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The Initial Treatment of Systemic Juvenile Idiopathic Arthritis: An...
Background/Purpose: The introduction of biologic medications has revolutionized the care of children with systemic juvenile idiopathic arthritis (SJIA). Differences in treatment approaches among...
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How Do Pediatric Rheumatologists Diagnose Macrophage Activation Syndrome in...
Background/Purpose: Macrophage activation syndrome (MAS) is a feared complication in~ 10% of those systemic onset juvenile idiopathic arthritis (sJIA). Due to the similarity of MAS clinical features to...
View ArticleParsing Apart the Pain Experience: Exploring Treatment-Related Pain in...
Background/Purpose: Pain is one of the most frequently reported symptoms among children with Juvenile Idiopathic Arthritis (JIA), and in recent decades our understanding and assessment of pain has...
View ArticleNailing Down Nailfold Capillaroscopy Practices: A Survey of Pediatric...
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by vasculopathy and rash. The Bohan-Peter criteria for dermatomyositis are not ideal. There is no...
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A Randomized, Double-blind, Placebo-controlled Study of Anakinra in Pediatric...
Background/Purpose: Adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA) are rare systemic disorders of auto-inflammatory nature. There is a growing understanding that...
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Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic...
Background/Purpose: Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease classically defined by the presence of circulating antiphospholipid antibodies and either thrombotic...
View ArticleCD3 Downregulation on T-cells Is Concomitant with Arginase Upregulation on...
Background/Purpose: Rationale: Juvenile idiopathic arthritis (JIA) is an inflammatory autoimmune disorder driven by dysfunction of the joint tissue and abnormal immune responses. As deep phenotyping of...
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Failure of Methotrexate Monotherapy and Subsequent Response to Tumor Necrosis...
Background/Purpose: Pediatric non-infectious uveitis is often treated with systemic immunomodulators in a step-wise fashion, with methotrexate (MTX) followed by tumor necrosis factor alpha inhibitors...
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Predictors of Moderate/High Disease Activity in Childhood-Onset Systemic...
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE), but there are limited studies identifying predictors...
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Medication Adherence in Adolescents and Young Adults with Childhood Onset SLE
Background/Purpose: Compared to adults with SLE, young patients with SLE face particular challenges, including more severe disease, more renal involvement and medications side effects like growth...
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Therapeutic Interferon Gamma Neutralization with Emapalumab in Patients with...
Background/Purpose: Interferon gamma (IFNγ) is a pivotal mediator of HLH. Emapalumab (a fully human anti-IFNγ monoclonal antibody) is efficacious in patients with primary HLH. In autoinflammatory...
View ArticleThe First 18 Months of a Pediatric Rheumatology Service at a Tertiary...
Background/Purpose: Pediatric rheumatic diseases impart a significant disease burden upon children and their families with the potential to cause diminished quality of life and significant direct and...
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Novel Algorithm to Increase Sensitivity of Detecting Active Arthritis in...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The use of infrared thermal imaging for screening JIA has not utilized standardized image...
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The Impact of Psychiatric Diagnosis and Treatment on Medication Adherence in...
Background/Purpose: Youth with systemic lupus erythematosus (SLE) experience significant health care burden and high rates of psychiatric disorders. Optimizing medication adherence is critical for...
View ArticleGenetic Susceptibility Loci for Periodic Fever, Aphthous Stomatitis,...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome of childhood. Although familial clustering of the...
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