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Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus
Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS) have identified more...
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Cyclophosphamide as Rescue Therapy for Kawasaki Disease with Peripheral...
Background/Purpose: Kawasaki Disease (KD) is the most common systemic vasculitis affecting children 5 years and younger. With coronary vessel involvement, KD is now the most common cause of acquired...
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Consequences and Predictors of Persisting Pain in Children with Juvenile...
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood. Pain is a distressing and prevalent feature of JIA and can decrease children’s quality of...
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A Good Inter- and Intra-observer Reliability of Subtypes in Nailfold...
Background/Purpose: In previous studies, micro-haemorrhages have often been observed in nailfold capillaroscopy in SLE.1 The interpretation of this finding is still a topic of research. Recently, a new...
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Reliability and Validity of a New Skin Activity Measure for Localized...
Background/Purpose: Juvenile localized scleroderma (jLS) is a chronic inflammatory and fibrosing disease. Treatment is directed towards controlling disease activity to minimize risk for functional...
View ArticleIs Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) a...
Background/Purpose: The improving therapeutic approach towards childhood-onset Takayasu’s arteritis (c-TA) has decreased the mortality rate over the years and increased concerns on how to improve...
View ArticleNear Infrared Indocyanine Green Imaging Reveals Altered Anatomy and...
Background/Purpose: Near infrared (NIR) imaging studies of subdermal indocyanine green (ICG) in murine models of inflammatory arthritis have established abnormal lymphatic vessel (LV) function during...
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The Efficacy and Safety of Intraarticular Injection of Triamcinolone...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. Intra-articular corticosteroids joint injection (IAJI) with Triamcinolone hexacetonide (TH) or...
View ArticleSuccessful Validation of a Rapid Point-of-care Test for Serum Calprotectin...
Background/Purpose: Treat-to-target strategies are established for the therapeutic approach to patients suffering from juvenile idiopathic arthritis (JIA). Another proposed therapeutic concept in...
View ArticleLow C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with...
Background/Purpose: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is characterized by sudden-onset OCD and additional neuropsychiatric symptoms. Imaging studies point to inflammation in the...
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Pediatric Rheumatology Consultation for Both Traditional and Emerging...
Background/Purpose: In addition to traditional rheumatic diseases (TRDs), Pediatric Rheumatologists are often consulted on emerging rheumatic diseases (ERDs) such as autoimmune encephalitis,...
View ArticleFamily Impact of Juvenile Localized Scleroderma
Background/Purpose: Juvenile localized scleroderma (jLS) is a rare autoimmune disease that can lead to significant morbidity. Previous studies have focused on predictors of patient health-related...
View ArticleUveitis Treatment in the CARRA II Registry: Tumor Necrosis Factor-inhibitors...
Background/Purpose: Uveitis associated with JIA (JIA-U) is the most common extra-articular complication of JIA. As JIA-U is associated with significant risk of visual loss and impairment, achieving...
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Vitamin C Deficiency: An Under-Recognized Cause for Pediatric Limb Pain
Background/Purpose: Vitamin C is essential in bone formation: it acts as a cofactor in forming and stabilizing the collagen triple helix. Exogenous intake of vitamin C is vital as humans cannot...
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Rheumatic Fever in a Tertiary Medical Center – 25 Years of Follow Up
Background/Purpose: Rheumatic Fever (RF) occurs after a pharyngeal infection caused by group A-B-hemolytic streptococci.Its principal clinical significance is causing carditis at the acute phase of the...
View ArticleAcceptability and Usability Testing of a Preliminary Version of the JIA...
Background/Purpose: Although juvenile idiopathic arthritis (JIA) is one of the most common causes of chronic musculoskeletal pain among youth, families’ decision-making for pain management is not...
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Improving Pneumococcal Vaccination Rates in Immunosuppressed Rheumatology...
Background/Purpose: The Centers for Disease Control and Prevention recommends pneumococcal vaccination of high-risk patients, including patients on iatrogenic immunosuppression. Many patients seen in...
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Myositis Autoantibodies in a Racially Diverse Population of Children with...
Background/Purpose: The presence of myositis specific autoantibodies (MSA) and myositis associated antibodies (MAA) has been associated with specific clinical phenotypes, various organ involvement and...
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Single Cell Sequencing of the Skin to Define Cell Populations of Interest in...
Background/Purpose: Scleroderma is an autoimmune disorder involving inflammatory driven fibrosis, which encompasses systemic sclerosis (SSc) and localized scleroderma (LS). LS and SSc share...
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