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Immersive Virtual Reality for Management of Amplified Musculoskeletal Pain...
Background/Purpose: Amplified Musculoskeletal Pain Syndrome (AMPS), a chronic pain syndrome with excessive musculoskeletal pain without a primary organic etiology, has a high prevalence in adolescents....
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Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in...
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody...
View ArticleMusculoskeletal Ultrasound Study in Childhood Arthritis: A Limited Examination
Background/Purpose: A challenge in the management of Juvenile Idiopathic Arthritis (JIA) is most of the core set of assessment measurements are subjective by nature. A validated, accessible, objective...
View ArticleEarly Treatment with Anakinra in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) should be considered as a polygenic autoinflammatory disease. Interleukin 1 (IL-1) has been shown to be a major mediator of the...
View ArticleAnti-Mitochondrial Autoantibodies Are Associated with Dysphagia in Juvenile...
Background/Purpose: We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in both juvenile-(JM) and adult-onset myositis cohorts and investigated phenotype differences between juvenile...
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Baseline Kidney Biopsy in Lupus Patients Without Renal Manifestations....
Background/Purpose: Lupus nephritis (LN) is seen in 20–75% of patients with pediatric Systemic Lupus Erythematosus (SLE). LN may present with abnormal urinary findings and/or renal impairment (overt...
View ArticleLong Term Safety of Biologics and Biosimilars in Pediatric Rheumatic...
Background/Purpose: The use of biologic response modifiers(BRMs) is associated with an increased risk of infections. We also use biosimilars for two reasons:1. originator not available, like...
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Chest Computed Tomography Manifestations in Childhood-Onset Systemic Lupus...
Background/Purpose: Intrathoracic involvement in adults with systemic lupus erythematosus (SLE) is relatively common, particularly pleural disease. The prevalence of intrathoracic involvement in...
View ArticleFunctional Characterization of PLCG2 Mutations Found in Subjects with...
Background/Purpose: PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID) are autosomal dominant diseases caused by mutations of PLCG2. APLAID is...
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The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4...
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified...
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Evaluation of Self-report Screening Measures in the Detection of Depressive...
Background/Purpose: Screening for co-morbid psychiatric disorder is of high clinical importance in childhood-onset systemic lupus erythematosus (cSLE). However, there are no validated screening...
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Long-Term Outcomes in Children Born to Anti-Ro and/or anti-La Positive Mothers
Background/Purpose: Neonatal Lupus Erythematosus (NLE) is an acquired autoimmune disorder associated with the transplacental passage of maternal anti-Ro and/or anti-La antibodies. NLE manifestations...
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Implications of Positive Tests for ANCA in a Pediatric Population
Background/Purpose: Testing for ANCA, particularly performed by ELISA (anti-MPO/PR3) is highly sensitive and specific for ANCA-associated vasculitis (AAV). However ANCA testing may be used in clinical...
View ArticleAdvanced Multidisciplinary Care: A New Approach to Childhood Arthritis
Background/Purpose: Many patients are overwhelmed with the diagnosis of chronic childhood arthritis and require long-term treatments. Our objective was to develop a new, child and family centered,...
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The Importance of the Patient Global Health Assessment of Disease Activity in...
Background/Purpose: Polyarticular juvenile idiopathic arthritis (pJIA) is a subtype of JIA wherein more than four joints are affected with arthritis; it is characterized by unpredictable flares and...
View ArticleClinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus...
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with...
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Change in Treatments and Outcomes After Implementation of a National...
Background/Purpose: Juvenile idiopathic arthritis (JIA) is currently the most common childhood chronic rheumatic disease with high burden and socioeconomic costs for the patient’s family and the health...
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Association of Plasma Metabolomic Profiles with Methotrexate Response in...
Background/Purpose: Despite efforts to identify biomarkers to guide therapy in the treatment of juvenile idiopathic arthritis (JIA), drug therapy remains a trial-and-error process. In the case of...
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Increasing Rates of Standardized Depression Screening in Youth with Systemic...
Background/Purpose: Depression is common among youth with SLE. Early identification and treatment of depression has the potential to improve health outcomes for youth with SLE. Pediatric...
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