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Levels of Anxiety and Depressive Symptoms in Juvenile Idiopathic Arthritis...
Background/Purpose: Children with chronic diseases have higher rates of mental health issues and less favorable outcomes than the general pediatric population. Children with JIA experience pain and...
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Parental Adverse Childhood Experience (ACE) Exposure Is Predictive of Active...
Background/Purpose: Adverse Childhood Experiences (ACEs) have been recognized for more than two decades as risk factors for poor health outcomes in adults. Nevertheless, the impact of patient exposure...
View ArticleMyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88...
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Double Negative T Cells in Juvenile Dermatomyositis
Background/Purpose: Double Negative (DN) T cells was initially described in the context of autoimmune lymphoproliferative disease, which is caused by defective T cells apoptosis due to mutation of the...
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Measuring Decision Conflict in Parents of Children with Juvenile Idiopathic...
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) and biologic agents are routinely used in the treatment of JIA and JIA-associated uveitis (JIA-AU). Parents are often fearful,...
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Evaluating the Relationship Between Juvenile Idiopathic Arthritis Disease...
Background/Purpose: JIA – associated uveitis (JIA-U) accounts for 20-40% of childhood noninfectious uveitis and affects 10-20% of patients with JIA. Its chronic course is often painless and insidious,...
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Discovering the Implications of Adiposity in Juvenile Dermatomyositis
Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several...
View ArticleAssociations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk for poor...
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Differences in Clinical Presentation Between Israeli and United States...
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US)....
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Transition from Pediatric to Adult Rheumatology: The Clinician as a...
Background/Purpose: The transition from pediatric to adult rheumatology is linked to poor outcomes in the absence of comprehensive transition programs. Several tools are available to measure transition...
View ArticleAncestry, Demographic and Clinical Features of Israeli Periodic Fever...
Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology. Recently, we showed that there may be a...
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HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile...
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by fibrosis and...
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Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with...
Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies in patients suggest that...
View ArticleLow C4 Copy Number of Total C4 Gene, C4B Gene and C4BL Gene in Children with...
Background/Purpose: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is characterized by sudden-onset OCD and additional neuropsychiatric symptoms. Imaging studies point to inflammation in the...
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Pediatric Rheumatology Consultation for Both Traditional and Emerging...
Background/Purpose: In addition to traditional rheumatic diseases (TRDs), Pediatric Rheumatologists are often consulted on emerging rheumatic diseases (ERDs) such as autoimmune encephalitis,...
View ArticleFamily Impact of Juvenile Localized Scleroderma
Background/Purpose: Juvenile localized scleroderma (jLS) is a rare autoimmune disease that can lead to significant morbidity. Previous studies have focused on predictors of patient health-related...
View ArticleUveitis Treatment in the CARRA II Registry: Tumor Necrosis Factor-inhibitors...
Background/Purpose: Uveitis associated with JIA (JIA-U) is the most common extra-articular complication of JIA. As JIA-U is associated with significant risk of visual loss and impairment, achieving...
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Vitamin C Deficiency: An Under-Recognized Cause for Pediatric Limb Pain
Background/Purpose: Vitamin C is essential in bone formation: it acts as a cofactor in forming and stabilizing the collagen triple helix. Exogenous intake of vitamin C is vital as humans cannot...
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Rheumatic Fever in a Tertiary Medical Center – 25 Years of Follow Up
Background/Purpose: Rheumatic Fever (RF) occurs after a pharyngeal infection caused by group A-B-hemolytic streptococci.Its principal clinical significance is causing carditis at the acute phase of the...
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